And Simon Weaver's side know that victory in the first ever encounter between the two sides will see them move to within a point of their opponents and put some daylight between those sides at the bottom end of the table.
AFC Wimbledon currently sit in 17th position in League Two, having taken 16 points from their 15 games so far in the 2022/23 season.
Unbeaten in their previous two games, they drew 1-1 at home to Crewe after taking all three points at Rochdale a week ago. Their four victories so far this season have all come against sides currently residing in the bottom six.
They have taken eight points from their seven fixtures at Plough Lane and are still searching for the level of consistency that will see them mount a promotion push to return to League One as the first time of asking.
The man in charge
Johnnie Jackson is in the dugout for tomorrow's visitors, having taken over at the club in the summer. Jackson was previously manager of Charlton Athletic, initially impressing on a caretaker basis before landing the job permanently.
Jackson also made over 400 appearances in his playing career for Tottenham, Colchester and Charlton.
Ones to watch
AFC Wimbledon have Josh Davison leading the way in the goal charts, having netted five times and the young forward has also added two assists so far. Nathan Young-Coombes has three goals and two assists whilst Ayoub Assal and Ethan Chislett have each hit the target on three occasions.
Veteran Chris Gunter will line-up in defence, likely alongside Lee Brown whilst Harry Pell will be a key figure in midfield having arrived at the club from Accrington Stanley shortly before the transfer window closed.
The story of AFC Wimbledon is a well-known one, with the club being formed 20 years ago after the sanctioning by the FA of the move for Wimbledon FC to relocate to Milton Keynes.
The new club restarted in the ninth tier of English football, earning six promotions to make its way back to the EFL in 2011, with a further promotion to League One in 2016 before suffering relegation last season.
The club also moved back to their previous ‘home' at Plough Lane in November 2020, with the ground built on the site of the old Wimbledon greyhound stadium just 250 years from the original Plough Lane.
Simon Weaver will have some selection issues to contend with as he will be without Will Smith, Max Wright, Stephen Dooley, George Thomson, Dior Angus, Josh Austerfield and Joe Mattock but will be hopeful that Jack Muldoon recovers from the injury has seen him miss the previous two games.